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The Philadelphia Eagles can clinch the NFC East when they visit the rival Washington Commanders on an NFL Saturday matchup. Philly (9-5) ended a three-game losing streak with a 31-0 shutout victory over the Las Vegas Raiders on Sunday. Washington (4-10) ended an eight-game losing streak by defeating the New York Giants, 29-21, in Week 15. Jayden Daniels has been declared out for the rest of the season, as Marcus Mariota will start for Washington.

Kickoff is at 5 p.m. ET from Northwest Stadium in Landover, Md. The Eagles won two of three matchups last season, including a playoff contest. Philadelphia is the 7-point favorite in the latest Eagles vs. Commanders odds, while the over/under for total points scored is 44.5 via DraftKings Sportsbook. Before making any Commanders vs. Eagles picks, check out the NFL predictions from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Commanders vs. Eagles. You can visit SportsLine now to see the picks. Here are the NFL odds and betting trends Eagles vs. Commanders:

Commanders vs. Eagles spread

Philadelphia -7 at DraftKings Sportsbook

Commanders vs. Eagles over/under

44.5 points

Commanders vs. Eagles money line 

Philadelphia -333, Washington +265

Commanders vs. Eagles picks

See picks at SportsLine

Commanders vs. Eagles streaming 

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Why the Eagles can cover

The last time these teams met -- in the 2025 NFC Championship Game -- Philly put 55 points on the scoreboard, which is the most in NFL history in any conference title game. Additionally, Philadelphia has owned this rivalry since Jalen Hurts entered the picture, as the team is 6-1 versus Washington in games Hurts starts and finishes, with the QB having 16 total touchdowns versus two interceptions. The Eagles' defense is also coming off its best performance in shutting out Vegas, and now it gets to face a Commanders team onto its backup quarterback, and one which doesn't have a defense to make up for Daniels' absence. Washington is No. 31 in total defense, with additional bottom-five rankings versus the run, versus the pass and in the red zone. See which team to back at SportsLine

Why the Commanders can cover

Washington is coming off scoring its second-most points (29) of the season on Sunday, and it still has a potent rushing attack even without Daniels. The Commanders boast the No. 4 rushing offense, averaging 141.8 yards over their last four games, and stopping the ground game is an issue for the Eagles. They are No. 22 in stopping the run, having allowed 165.3 yards over their last three games, and Philly can also be sloppy with the ball, having committed nine turnovers over their last four games. Also, Washington has covered in two of its last three games overall, while Philly is just 1-3 ATS in divisional games this year. See which team to back at SportsLine.

How to make Eagles vs. Commanders picks

SportsLine's model has simulated Commanders vs. Eagles 10,000 times and is going Over on the total, projecting 48 combined points. It also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. 

So who wins Eagles vs. Commanders, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Commanders vs. Eagles spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks since its inception, and find out.